TOKYO UNIVERSITY OF SCIENCE TAKAHASHI TSUJI'S LABORATORY

AApproach from ATLL specific multilobulated nucleus formation

Since specific multilobulated nuclei is induced at the onset of ATLL, we studied the pathway related the induction of that nuclear alternation in T cells isolated from chronic-type ATLL patients, multilobulated nucleus formation was significantly induced by AILIM/ICOS signaling (left figure a).

To examine the mechanisms of ATLL type multilobulated nucleus formation, we generated the AILIM/ICOS overexpressed-Jurkat cells to be induced the ATLL type nucleus formation, as analytical model cell line (left figure b).