TOKYO UNIVERSITY OF SCIENCE TAKAHASHI TSUJI'S LABORATORY

The mechanisms of ATLL type multilobulated nucleus formation and tumorigenesis

We next studied more detail mechanisms of ATLL type multilobulated nucleus formation. We found that the expressions of PIP3 phosphatases such as PTEN and SHIP-1, negative regulators of PI3-kinase cascade, were reduced and consequently leads to the abnormal activation of PI3-kinase cascade in the cells, which showed ATLL type multilobulated nucleus formation.

That abnormal activation of PI3-kinase cascade leaded to not only the induction of ATLL type multilobulated nucleus formation but also the abnormal phosphorylation of Akt and irregular cellular proliferation.

These results indicated that the molecular mechanisms of ATLL type tumorigenesis is clarified by the study of multilobulated nucleus formation.