3-dimensional Angio-architectonics
Reconstruct three-dimensional vascular network by reproduction
Important three-dimensional vascular network for organogenesis and its maintenance Adult cells can maintain high-density three-dimensional organs because blood is supplied via blood vessel route for gas exchange and material transport.
The two-dimensional cells can be cultured in the current culture system, but the three-dimensional culture of cells and tissues cannot be established yet. For realization of organ replacement regenerative therapies with bioengineered organ, we believe it is indispensable to construct three-dimensional vascular network.
Figure: Fluorescent imaging of microvessel in vivo.
Thin blood vessel is approximately 2-3μm.
Functional organ regeneration by constructing three-dimensional vascular network
Construction of vascular network may be regulated by some functions of perivascular cells and the work quantity or metabolic rate of those cells. This may be the ideal way to construct three-dimensional vascular plexus, basing the organ design and capacity on the cellular work quantity, and calculating the required volume, surface area, and exchange efficiency of the blood vessels.
From this perspective, we aim to regenerate the organs by reproducing the three-dimensional vascular network to disseminate the targeted functional cells.
