TOKYO UNIVERSITY OF SCIENCE TAKAHASHI TSUJI'S LABORATORY

Strategy of future tooth regenerative therapy

As described by many experts in the dental field, four major hurdles must be overcome to enable us to develop the tooth regenerative therapy. One is the improvement p of a bioengineering method for three-dimensional organ germs using single cells. Secondly, we must clarify the development of the bioengineered tooth germ in adult oral environment. Thirdly, the application of dental regenerative therapy, in practice, may be optimized by using the patient’s own cells for the prevention of immunological rejection by allogenic transplantation. Finally, the transplantation of the morphological‐controlled regenerated tooth would be better by in vitro organ processing. To generate a complete, entirely bioengineered tooth by transplantation of bioengineered tooth germ, four major obstacles need to be overcome.