TOKYO UNIVERSITY OF SCIENCE TAKAHASHI TSUJI'S LABORATORY

Histology of the bioengineered teeth

We found the teeth to have a correct tooth structure, such as ameloblast, enamel, dentin, odpntoblasts, blood vessels in pulp, alveolar bone and periodontal ligament‐like structure on the dentin‐side. From these results, it’s clear that the high‐cell density and cell compartmentalization are essential for the tooth development.

In above study, we developed a novel bioengineered method, which is a cell aggregate method, to reconstitute a three-dimensional organ germ in an early stage, termed a “bioengineered organ germ methods”. Our model improves understanding of principles by which organ reconstitution can be achieved with tissues that have been bioengineered in vitro and increases the potential for bioengineered organ replacement in the future.