TOKYO UNIVERSITY OF SCIENCE TAKAHASHI TSUJI'S LABORATORY

Regeneration of tooth that cooperates in maxilofacial region

Next, we analyzed the development of a bioengineered tooth germ transplanted into adult oral environment. To develop a tooth regenerative method for a clinical application, a bioengineered tooth should achieve full functionality, including sufficient masticatory performance, biomechanical cooperation with tissues in the oral and maxillofacial regions, and proper responsiveness via sensory receptors to noxious stimulations in the maxillofacial region.

Recently, we developed an adult murine lost tooth transplantation model. After the extraction of first molar, its cavity was repaired by osteogenesis for a month. Then, a hole was prepared in alveolar bone using drill. Then, a bioengineered molar tooth germ was transplanted into the hole with correct orientation and gingival transplantation area was sutured.