TOKYO UNIVERSITY OF SCIENCE TAKAHASHI TSUJI'S LABORATORY

Status of the achievement of matter

In above study, we successfully demonstrated that our bioengineered tooth germ develops into a fully functioning tooth with sufficient hardness for mastication and a functional responsiveness to mechanical stress in the maxillofacial region. We also show that the neural fibers that have re-entered the pulp and PDL tissues of the bioengineered tooth have proper perceptive potential in response to noxious stimulations such as orthodontic treatment and pulp stimulation. These findings indicate that bioengineered tooth generation techniques can contribute to the rebuilding of a fully functional tooth.